Zebra
ZD621
Desktop Printing — Standard & Healthcare Editions
The Zebra ZD621 is a premium 4-inch desktop printer engineered for flexibility, performance, and ease of use. Available in standard and HC (HealthCare) versions, it supports both thermal transfer and direct thermal printing, delivers up to 8 ips, and features advanced Zebra Print DNA tools. The Healthcare variant adds disinfectant-ready plastics, sealed buttons, and a medical-grade power supply for safe use in clinical environments.

Flexible Printing Modes — Choose between thermal transfer for durable, long-lasting labels, or direct thermal for quick, ribbon-free workflows.
Print Speed & Resolution — Up to 8 inches per second (203 mm/s), with models available at both 203 dpi and 300 dpi for better detail when needed.
Healthcare-Focused Hygiene — The ZD621-HC variant includes disinfectant-ready materials, sealed buttons, UV-resistant housing, and complies with power supply standards for medical equipment. Ideal for hospitals, labs, and clinical settings.
Comprehensive Connectivity & Management — Standard Ethernet, USB, Serial, and USB Host; optional dual wireless radio (802.11ac Wi-Fi + Bluetooth 4.1). Comes with Zebra’s Print DNA suite for remote management, enhanced security, and device setup via Bluetooth Low-Energy.
User Friendly Interface — Large 4.3-inch full-colour touch LCD display, intuitive controls, status LED icons make operation and media loading easy.
eature | ZD621 Standard Edition | ZD621-HC (Healthcare) Variant |
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Print Methods | Thermal Transfer + Direct Thermal | Same printing methods |
Print Speed | Up to 8 ips (203 mm/s) | Same speed cap |
Resolutions Offered | 203 dpi standard, 300 dpi option for finer detail | Same resolution options |
Maximum Print Width | Approx. 4.25 in / 108 mm media width | Same media width capability |
Media Handling | Roll-fed or fan-fold labels, die-cut, continuous, receipt paper; labels/tags. Multiple sensors (gap, black mark, etc.) | Same categories; HC model includes movable sensor for greater compatibility |
Interface & Connectivity | Ethernet, Serial, USB 2.0, USB Host; optional dual radio WiFi + Bluetooth; BLE for mobile setup | Same, plus healthcare-appropriate power supply and sealed controls |
Special Healthcare Features | — | Disinfectant-ready plastics, sealed button interface, IEC60601-1 certified power supply; easier to clean & sanitize in clinical settings. |
Software & Security | Runs Zebra Link-OS / Print DNA; supports ZPL II, EPL2; virtual device emulation; PrintSecure tools. | Same, with added focus on infection control and hygiene in design |