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Zebra

ZD421

Desktop Printing — Standard & Healthcare-Grade Editions


The Zebra ZD421 is a versatile 4-inch desktop printer built for modern workflows. Available in both standard and HC (HealthCare) versions, it supports thermal transfer or direct thermal printing, offers high print clarity, fast setup, and full connectivity. The HC version adds disinfectant-ready materials, sealed buttons, and medical-grade power compliance for safe, hygienic use in clinical settings.

ZD421

Flexible Print Modes — Choose between direct thermal for ribbon-free fast tasks, or thermal transfer for durable, longer-life labels. 

High Clarity & Compatibility — Available in both 203 dpi and 300 dpi resolutions, suitable for quality graphics, small barcodes, tags, receipts, and wristbands. 

Healthcare-Ready Features (HC Version) — Disinfectant-ready plastics, UV-resistant housing, sealed button interface, and a medically compliant power supply make the HC model safe and easy to sanitize. 

Strong Connectivity Options — Standard USB 2.0 + USB Host; optional Ethernet, serial, and dual wireless (802.11ac Wi-Fi + Bluetooth 4.1). Mobile app support via BLE for easy setup. 

Media Handling & Ribbon Flexibility — Supports up to approx. 104 mm (4.09 in) print width; large roll capacity; movable media sensors; ribbon cartridge options to simplify ribbon changes.

FeatureZD421 StandardZD421-HC (Healthcare)
Print MethodsDirect Thermal & Thermal Transfer Same methods; with design and component changes for hygiene & healthcare compliance 
Resolutions203 dpi standard; 300 dpi option for finer detail Same 203/300 dpi options 
Max Print SpeedUp to 6 ips (203 dpi) Same speed profile; HC model maintains same firmware/hardware under sealed conditions 
Print Width / Media WidthMax print width ~104 mm (4.09 in) Same media/print width; healthcare housing in HC version 
Memory & Processor512 MB Flash; 256 MB SDRAM; standard operating memory; supports ZPL II and EPL2. Same core memory; HC version may include updated firmware for health compliance and power supply differences 
Connectivity & InterfacesUSB 2.0, USB Host; optional Ethernet, Serial, dual wireless radio; BLE, NFC Print Touch tag. Same set; HC version retains all connectivity but with sealed buttons and disinfectant-safe materials. 
Housing & Physical FeaturesDesktop design; color-coded media guides; openACCESS for easy media/ribbon changes; roll supports etc. HC version with disinfectant-ready plastics, UV-stable housing, sealed buttons; designed for safe cleaning/sanitisation protocols. 
Dimensions & WeightApprox 220.8 × 177.5 × 150.7 mm; weight ~1.35-2.3 kg depending on model & configuration. Similar dimensions; HC variant slightly heavier owing to reinforced/different materials.

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